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blankPost-amputation pain/Stump pain

Post-amputation pain is a collection of neuropathic pain syndromes that occur following limb amputation. Chronic neuropathic pain after amputation is a significant medical problem, with reported incidence during the first year after amputation of up to 70% and is often a disabling condition for amputees.

Stump pain is defined as pain localized to the remaining part of the amputated limb. The pain may be located within a specific peripheral nerve distribution or may be more widespread. Patients may experience a variety of different pain types, including deep aching pain, burning, pressure, or lancinating pain.

As for other chronic pain syndromes, a ladder of treatment options beginning with the simplest and least invasive, progressing to the more complex and invasive, should be undertaken. The anticonvulsants, antidepressants, and opiates are typical drug options. Nerve blocks can be used when pharmacologic measures fail. Currently there is no approved pain drug with documented effect against post-amputation pain.

The company initiated its first pivotal phase III trial in stump pain/post amputation pain in early 2009. The study is designed as a two arm, placebo-controlled trial over 3 months, involving 100 patients in 5 countries in Northern Europa and Russia. The recruitment into the trial is ongoing and the company is expecting the trial to report during the 2nd half 2010.

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Osteoarthritis of the knee

In the US alone more than 20 million patients are suffering from osteoarthritis. Global sales in in the osteoarthritis market 2007 were approximately USDbn 4, around 15% oof the global pain market, and the market is expected to grow 3% annually to reach USDbn 5.5 in 2017 (Datamonitor).


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